PhD Candidate Profile: Golam Sarower Bhuyan

15 December 2020

What is your research about?

My PhD project aims to investigate the mechanism of Azacitidine (AZA) drug action in Myelodysplastic Syndromes (MDS) patients. MDS are highly common among the elderly people and the patients frequently progress to acute myeloid leukemia. AZA is the only approved drug for treating higher risk MDS patients but effective only in half of the cases. Moreover, the benefit is transient and the disease relapse within two years. Yet, it is not known how AZA improves the condition in some of the MDS patients.

What is the translational application of your research?

I will perform single cell sequencing and transcriptomic analysis using blood-forming cells of the MDS patients who responded to AZA treatment. The objective is to find whether AZA eliminate defective blood-forming cells or reform them to improve the condition. Understanding the AZA action will help to improve the current treatment approach or find alternative treatment agents for treating MDS patients.

How would the TCRN PhD top-up Scholarship help you succeed?

The TCRN scholarship is a boost for my career. It enabled me to network with professionals and other PhD students of the same academic field which would help me to improve my current project as well as open opportunities for future research. The personal experiences and stories of each TCRN consumers are an immense motivation for me. I would be delighted if my project can contribute to improving the treatment of MDS patients.